Publications by authors named "B Rankov-Petrovic"

Article Synopsis
  • Anxiety is a common psychiatric disorder linked to multiple factors, including maternal hormone levels during pregnancy.
  • Research showed that female offspring of rats subjected to maternal hyperandrogenemia (high testosterone) showed increased anxiety-like behaviors and decreased expression of neuropeptide Y (NPY) and parvalbumin (PV) in the hippocampus.
  • Additionally, while brain-derived neurotrophic factor (BDNF) levels were increased in the hippocampus and cerebral cortex, the overall findings suggest that prenatal high testosterone can contribute to anxiety disorders in offspring through specific changes in brain chemistry.
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The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and l-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of dl homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)).

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The aim of this study was to examine the effects of a methionine-enriched diet on anxiety-related behavior in rats and to determine the role of the brain oxidative status in these alterations. Adult male Wistar rats were fed from the 30th to 60th postnatal day with standard or methionine-enriched diet (double content comparing with standard diet: 7.7 g/kg).

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Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats.

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