Publications by authors named "B Rakel"

Aim: To describe our methods to compare patient-reported symptoms of acute myeloid leukemia and the corresponding documentation by healthcare providers in the electronic health record.

Background: Patients with acute myeloid leukemia experience many distressing symptoms, particularly related to chemotherapy. The timely recognition and provision of evidence-based interventions to manage these symptoms can improve outcomes.

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Article Synopsis
  • - The study investigates the genetic factors contributing to chronic post-surgical pain (CPSP) by analyzing data from 1,350 individuals who underwent various types of surgery, and highlights a significant genetic component, estimating a 39% heritability for CPSP through meta-analysis.
  • - Researchers identified 77 key genetic variations (SNPs) linked to CPSP and noted that most of these are associated with immune system genes, especially those related to B and T cells.
  • - Animal studies showed that mice without T and B cells experienced worsened pain after surgery, which could be mitigated by transferring B cells, suggesting that the adaptive immune system plays a crucial protective role against CPSP.
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Introduction: Black persons bear a disproportionate burden of peripheral artery disease (PAD) and experience higher rates of endovascular revascularization failure (ERF) when compared with non-Hispanic White persons. We aimed to identify predictors of ERF in Black persons using predictive modeling.

Methods: This retrospective study included all persons identifying as Black who underwent an initial endovascular revascularization procedure for PAD between 2011 and 2018 at a midwestern tertiary care center.

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The sudden onset of the coronavirus disease led to a rapid expansion of video telehealth to deliver mental healthcare. Although video telehealth was not a new clinical practice, there was limited guidance on how best to modify evidence-based psychotherapies (EBPs) for virtual delivery (a process also referred to as virtualization). The virtualization process for EBPs remains unclear as newly emerging reports on this topic do not consistently report modification decisions.

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Wound dressing changes are essential procedures for wound management. However, ~50% of patients experience severe pain during these procedures despite the availability of analgesic medications, indicating a need for novel therapeutics that address underlying causes of pain. Along with other clinical factors, wound pathogens and inflammatory immune responses have previously been implicated in wound pain.

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