Proteoglycans in human coronary arteriosclerotic lesions.

Proteoglycans in human coronary arteries were characterized immunohistochemically, using specific monoclonal antibodies to distinct proteoglycan types. In addition, apoB, macrophage, and arterial smooth muscle cell alpha-actin markers were localized. The expression of chondroitin sulfate proteoglycans and apoB was observed in healthy areas (operationally defined by morphology) as well as in lesions in the intima, but with greater expression in the atheromatous lesions.

Racial (black-white) differences in insulin secretion and clearance in adolescents: the Bogalusa heart study.

Objective: Earlier we found black-white contrast in insulin levels in adolescents. The purpose of this study is to assess whether this difference is attributable to alterations in insulin secretion and/or clearance.

Methods: Fasting circulating insulin and C-peptide concentrations were examined in 1157 adolescents aged 11 to 18 years from a biracial community.

Urinary N-acetyl-beta-D-glucosaminidase changes in relation to age, sex, race, and diastolic and systolic blood pressure in a young adult biracial population. The Bogalusa Heart Study.

Increased urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been reported in many clinical conditions, including essential hypertension. Since hypertension is increasingly recognized as beginning in childhood, we hypothesized that urinary NAG changes with increasing blood pressure may start early in life and may also be the evidence of the existence of early hypertensive disease. We analyzed the urinary NAG changes in 980 young adults, ages between 18 to 32, in relation to age, race, sex, and systolic and diastolic blood pressure.

Does adult-onset diabetes mellitus begin in childhood?: the Bogalusa Heart Study.

Children and young adults (N = 52, age 7-31, average 15.3 years) from parents with or without a history of onset of diabetes mellitus after the age of 30 years were studied for anthropometric and metabolic parameters related to diabetes. An oral glucose tolerance test was performed and blood samples were collected fasting and 15, 30, and 60 minutes after a standard glucose load.