Publications by authors named "B R Vundinti"
Article Synopsis
- Acquired aplastic anemia (AA) often leads to the immune destruction of blood-forming stem cells, but only 60-70% of patients respond to immunosuppressive therapy (IST), highlighting the need for better predictive markers.* -
- A study involving 51 severe AA patients analyzed various immune parameters and found a unique immune profile in patients, including reduced Treg counts and a distinct CD4/CD8 ratio, which could help in understanding treatment responses.* -
- Although some correlations were noted between treatment response and specific blood counts, established predictors like telomere length and PNH did not serve as reliable indicators, indicating that identifying treatment predictors in AA is complex due to various influencing factors.*
Introduction: Myelodysplastic syndrome (MDS) is a heterogeneous disease characterized by cytopenia, marrow dysplasia and has a propensity to develop into acute myeloid leukemia. The disease progression is majorly affected by genetic defects. However, about 40-50% of patients with MDS present with a normal karyotype and develop different courses of disease.
View Article and Find Full Text PDFLiving organisms are exposed to exogenous and endogenous agents that affect genomic integrity by creating DNA double strand breaks (DSBs). These breaks are repaired by DNA repair proteins to maintain homeostasis. Defects in DNA repair pathways also affect lymphocyte development and maturation, as DSB sites are critical intermediates for rearrangements required for V(D)J recombination.
View Article and Find Full Text PDFCongenital amegakaryocytic thrombocytopenia (CAMT) is a rare, genetic, autosomal recessive disorder characterized by severe thrombocytopenia, due to inefficient bone marrow megakaryopoiesis eventually leading to aplasia. Majority of the cases are due to homozygous or compound heterozygous mutations in MPL gene encoding for thrombopoietin (THPO) receptor protein. CAMT can be diagnosed at early phase of life, with major complication of transfusion dependency and hematopoietic transplantation as only curative treatment.
View Article and Find Full Text PDFContext: Chromosomal abnormalities play an important role in diagnosis and prognosis of hematological diseases.
Aims: The aim of the present study was to study the pattern and frequency of chromosomal aberrations in acute myeloid leukemia (AML) subgroups from western India.
Settings And Design: A retrospective study was conducted through evaluating laboratory proforma which were filled during 2005 to 2014 for diagnosis and treatment of AML subjects.