Publications by authors named "B R Stevenson"
The presentation of comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) differs by substance type. The current study applied network analysis to explore the relationships between diagnostic symptom clusters by examining the strength and direction of unique associations between PTSD and SUD. Network analyses were estimated using a sample of 422 veterans diagnosed with co-occurring PTSD/SUD initiating psychotherapy for PTSD while receiving concurrent outpatient SUD treatment as part of a randomized clinical trial.
View Article and Find Full Text PDFPurpose: Thrombotic cardiovascular diseases profoundly impact patients' health-related quality of life (HRQoL). However, patient-reported outcome (PRO) instruments that are disease-specific or antithrombotic-treatment focused, developed according to US Food and Drug Administration (FDA) guidance on PROs, and can be used in clinical trials, are lacking. The aim of this study was to understand concepts important to patients diagnosed with coronary artery disease (CAD) or acute coronary syndrome (ACS), atrial fibrillation (AF), or stroke who require antithrombotic treatment for reducing risk of future thrombotic events (indications being evaluated for an investigational new drug), identify PROs that measure relevant symptoms and impacts, and determine acceptability of PROs from a health technology assessment (HTA) perspective.
View Article and Find Full Text PDFArticle Synopsis
- - Glutathione (GSH) is an important tripeptide that protects cells from oxidative stress and removes toxic heavy metals, with the study focusing on its coordination with metals essential for biological redox processes: Zn, Cu, and Fe.
- - Using infrared multiple photon dissociation (IRMPD) spectroscopy, researchers identified complexes formed between these metals and deprotonated GSH, revealing significant differences in metal coordination preferences based on experimental and theoretical vibrational spectra.
- - The findings highlight common spectral features among the metal complexes while also indicating that the cysteine component of glutathione plays a crucial role in coordinating with these metals, which is relevant for understanding their biochemical functions.
Metalated intact and deprotonated histidyl glycine and glycyl histidine dipeptides were investigated in the gas phase by using infrared multiple photon dissociation (IRMPD) spectroscopy with light from a free-electron laser (FEL). The dipeptides M(GlyHis), M(HisGly), [M(GlyHis-H)], and [M(HisGly-H)], where M = Zn and Cd, were probed to elucidate how the His position along the peptide chain and ligand charge state might influence the structures observed in the gas phase. Simulated annealing calculations were performed to determine energetically low-lying conformers and isomers of these structures.
View Article and Find Full Text PDFArticle Synopsis
- Wastewater surveillance was utilized during the COVID-19 pandemic to monitor the transmission of SARS-CoV-2, focusing on timely identification of emerging variants, especially Omicron.
- The Oklahoma Wastewater Surveillance team used allele-specific RT-qPCR assays to detect variants, finding Omicron in wastewater about two weeks prior to official reports, confirmed by genomic sequencing.
- The study observed a shift from Delta to Omicron prevalence in local communities and linked this transition to various demographic factors, showing the effectiveness of RT-qPCR as a method for tracking SARS-CoV-2 variants.