Publications by authors named "B R Stanton"
Background: Current US federal action levels for domoic acid (DA) in seafood are based on acute toxicity observed in exposed adult humans. Life course considerations have not been incorporated. The potential for developmental neurotoxicity (DNT) at permissible DA levels has previously been noted, but not methodically assessed.
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- - Functional Neurological Symptom Disorder (FNSD) involves neurological-like symptoms without a clear neurological cause, and the mechanisms behind it are complex and not fully understood.
- - A study tested the use of remote monitoring technologies (RMT) on 17 individuals with FNS and 17 healthy controls to track symptoms, daily events, and physiological data, finding that those with FNS reported higher levels of negative emotions, pain, and sleep issues.
- - Results indicate that daily stressors and negative feelings significantly impact FNS severity, suggesting that addressing emotional responses could help those with FNS, and calls for larger studies to explore these findings further.
Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function.
Am J Physiol Lung Cell Mol Physiol
December 2024
The combination of elexacaftor/tezacaftor/ivacaftor (ETI, Trikafta) reverses the primary defect in cystic fibrosis (CF) by improving CFTR-mediated Cl and HCO secretion by airway epithelial cells (AECs), leading to improved lung function and less frequent exacerbations and hospitalizations. However, studies have shown that CFTR modulators like ivacaftor, a component of ETI, have numerous effects on CF cells beyond improved CFTR channel function. Because little is known about the effect of ETI on CF AEC gene expression, we exposed primary human AEC to ETI for 48 h and interrogated the transcriptome by RNA-seq and qPCR.
View Article and Find Full Text PDFUnlabelled: E.PathDash facilitates re-analysis of gene expression data from pathogens clinically relevant to chronic respiratory diseases, including a total of 48 studies, 548 samples, and 404 unique treatment comparisons. The application enables users to assess broad biological stress responses at the KEGG pathway or gene ontology level and also provides data for individual genes.
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