Publications by authors named "B R Sommer"

Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat.

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Idiopathic pulmonary fibrosis (IPF) is a chronic, deathly disease with no recognized effective cure as yet. Furthermore, its diagnosis and differentiation from other diffuse interstitial diseases remain a challenge. Circulating miRNAs have been measured in IPF and have proven to be an adequate option as biomarkers for this disease.

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Background: Tirofiban is administered for the treatment of aneurysms in cases of thromboembolic complications, as well as in cases of acute stenting or flow-diverter implantation required within the scope of aneurysm treatment. We aimed to investigate the efficacy and safety of tirofiban in this group of patients.

Methods: We conducted a retrospective analysis of all patients undergoing aneurysm treatment and receiving peri-interventional tirofiban administration at our institution between 2009 and 2019.

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Prolonged antibiotic therapy is often recommended for the treatment of spinal infections. This study aimed to evaluate the efficacy and safety of outpatient intravenous (IV) antibiotic therapy for spinal neurosurgery patients with spondylodiscitis. We carried out a retrospective study involving 67 patients who were administered peripherally inserted central catheter (PICC) for IV antibiotic treatment from January 2020 to December 2022.

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Article Synopsis
  • The study investigates how a family history of type 2 diabetes (FH-DM2) affects the function of endothelial cells (ECs) using human umbilical vein endothelial cells (HUVECs) as a model.
  • Researchers measured various factors including reactive oxygen species (ROS), nitric oxide (NO) synthesis, mitochondrial activity, and glucose metabolism in HUVECs from newborns with FH-DM2.
  • Results indicated that HUVECs from these newborns showed impaired synthesis of ROS and NO, changes in cell complexity and size, and reduced glucose consumption, which highlight early endothelial dysfunction linked to FH-DM2 and may help in preventing cardiovascular diseases.
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