Publications by authors named "B R Sellman"
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and accelerated lung function decline. The relationship with immune responses and NTHi are poorly understood.
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- Candida albicans and Staphylococcus aureus are linked pathogens that cause serious hospital infections, leading to high rates of illness and death.
- Research using a mouse model showed that Candida promotes increased virulence of Staphylococcus by enhancing the production of a harmful toxin, which worsens infections.
- A study uncovered that a specific transcription factor (ZCF13) in C. albicans is crucial for utilizing ribose, which inhibits the harmful effects of Staphylococcus; the absence of ZCF13 leads to increased toxicity and severity of infections.
Single monoclonal antibodies (mAbs) can be expressed in vivo through gene delivery of their mRNA formulated with lipid nanoparticles (LNPs). However, delivery of a mAb combination could be challenging due to the risk of heavy and light variable chain mispairing. We evaluated the pharmacokinetics of a three mAb combination against Staphylococcus aureus first in single chain variable fragment scFv-Fc and then in immunoglobulin G 1 (IgG1) format in mice.
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- Patients with bronchiectasis experience worse health outcomes due to infections, often linked to weakened neutrophil antimicrobial responses that allow bacteria to persist.
- The study investigated the effectiveness of gremubamab, a bispecific monoclonal antibody, in boosting the ability of neutrophils to kill bacteria associated with bronchiectasis.
- Results showed that gremubamab significantly improved neutrophil functions, including opsonophagocytic killing and phagocytosis, without interfering with the body's natural antibodies, thus reducing the harmful effects of the bacterial infection.*
and are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior and current work using a murine model of polymicrobial intra-abdominal infection (IAI) uncovered synergistic lethality that was driven by -induced upregulation of functional ⍺-toxin leading to polymicrobial sepsis and organ damage. In order to determine the candidal effector(s) mediating enhanced virulence, an unbiased screen of transcription factor mutants was undertaken and revealed that Δ/Δ failed to drive augmented ⍺-toxin or lethal synergism during co-infection.
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