Biomarkers.

Background: The immune system is substantially involved in the development and progression of age-related cognitive decline and Alzheimer's disease (AD).

Method: As genetic and environmental factors interactively impact these conditions, we investigated how risk factors such as APOE genotype, age, and sex influence immune activation markers and AD biomarkers in cerebrospinal fluid (CSF) in elderly individuals enrolled in the Mayo Clinic Study of Aging cohort. Among cognitively unimpaired individuals aged over 65 at the baseline visit (N=298), we measured 365 CSF immune activation markers using the proximity extension assay.

Alzheimer's Imaging Consortium.

Background: The immune system is substantially involved in the development and progression of age-related cognitive decline and Alzheimer's disease (AD).

Method: As genetic and environmental factors interactively impact these conditions, we investigated how risk factors such as APOE genotype, age, and sex influence immune activation markers and AD biomarkers in cerebrospinal fluid (CSF) in elderly individuals enrolled in the Mayo Clinic Study of Aging cohort. Among cognitively unimpaired individuals aged over 65 at the baseline visit (N=298), we measured 365 CSF immune activation markers using the proximity extension assay.

Drug Development.

Background: Homozygosity for the rare APOE3-Christchurch (APOE3Ch) variant, encoding for apoE3-R136S (apoE3-Ch), was linked to resistance against an aggressive form of familial Alzheimer's disease (AD). Carrying two copies of APOE3Ch was sufficient to delay autosomal AD onset by 30 years. This remarkable protective effect makes it a strong candidate for uncovering new therapies against AD.

Lack of Vertical Transmission of Grapevine Red Blotch Virus by and Sex-Associated Differences in Horizontal Transmission.

Grapevine red blotch is an emerging disease that threatens vineyard productions in North America. Grapevine red blotch virus (GRBV, species , genus , family ), the causal agent of red blotch disease, is transmitted by (Hemiptera: Membracidae) in a circulative, non-propagative mode. To gain new insight into GRBV- interactions, we delved into vertical transmission and documented a lack of transovarial transmission.

First seroprevalence survey of bovine anaplasmosis: an emerging tick-borne disease in commercial livestock and dairy farms in Bangladesh.

Bovine anaplasmosis is an infectious, tick-borne disease caused by species, which is accountable for huge economic loss in dairy industry. This study was aimed to determine the seroprevalence of bovine anaplasmosis on randomly selected 61 commercial dairy farms in 3 intensive regions of Bangladesh. A total of 1472 sera were analysed using VMRD Antibody Test Kit cELISA v2 for the presence of -specific antibodies.