Publications by authors named "B R Pattnaik"
Objective: To assess the effects of inferior vena cava and/or hepatic vein (IVC±HV) venoplasty on liver volumetry and function in individuals with Budd Chiari syndrome (BCS) who present with ascites and at least one patent hepatic vein.
Methods: A retrospective analysis was conducted on the clinical data of 17 patients with BCS (6 males and 11 females, average age of 42.3 ± 11.
Genetic medicines, including CRISPR/Cas technologies, extend tremendous promise for addressing unmet medical need in inherited retinal disorders and other indications; however, there remain challenges for the development of therapeutics. Herein, we evaluate genome editing by engineered Cas9 ribonucleoproteins (eRNP) in vivo via subretinal administration using mouse and pig animal models. Subretinal administration of adenine base editor and double strand break-inducing Cas9 nuclease eRNPs mediate genome editing in both species.
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- Differentiating liver tumors is crucial for appropriate treatment and prognosis, but non-invasive methods often struggle due to overlapping features in imaging.
- This study evaluated CT perfusion parameters in 48 patients to help distinguish hepatocellular carcinoma (HCC) from other liver tumors, using statistical analysis to identify significant perfusion metrics.
- Results indicated that blood volume (BV) was particularly effective in differentiating HCC from other tumors, achieving a sensitivity of 96.6% and specificity of 80% at a threshold of 8.3 ml/100 ml/min, alongside several other significant perfusion parameters.
Left-sided portal hypertension (LPH) refers to increased splenic venous pressure caused by splenic vein stenosis or occlusion. Pancreatitis is the leading cause of LPH. Typically, LPH remains asymptomatic, but it can lead to life-threatening hemorrhage from ruptured fundal varices in about 10% of patients.
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