Pain control and analgesic requirements following laparoscopy-assisted transversus abdominus plane (TAP) block compared to port site infiltration post-paediatric laparoscopic appendicectomy. A Randomised controlled trial.

Background: Appendicectomy is a common procedure in children. Regional anaesthesia helps reduce requirements for opioids and hospital stay and enhances recovery. Laparoscopic-assisted Transversus Abdominus Plane block (L-TAP) was shown to be efficient and potentially superior to port site infiltration (PSI); however, this was not previously studied in paediatric appendicitis.

Phase 2 Open-Label Trial of Brentuximab Vedotin with Pembrolizumab in PD-1 Pretreated Metastatic Non-Small Cell Lung Cancer and Metastatic Cutaneous Melanoma.

Purpose: Brentuximab vedotin (BV) is hypothesized to selectively deplete T regulatory cells (Tregs) that express CD30 and re-sensitize tumors to anti-(PD-1) therapy. This study evaluated responses to BV+pembrolizumab post PD-1 and explored corresponding biomarkers.

Methods: 55 patients with metastatic non-small cell lung cancer (NSCLC) and 58 with metastatic cutaneous melanoma received ≥1 dose of BV+pembrolizumab.

Delivering family centred services in child-onset disability: a mixed methods approach to understanding health professionals' experiences and approaches.

Aim: Family-centred service aims to build family capacity to support their children, but behaviours supporting capacity-building vary. We explored what influences the way service providers think about and approach family-centred service.

Method: An online survey drew on experiences, beliefs, and perspectives of Australian providers.

Exploring the impact of professional development about family-centred service for health professionals working in paediatric disability: a scoping review.

Purpose: To explore the impact of family-centred service education on the knowledge, attitudes, self-efficacy, and practice of service providers working in paediatric disability.

Materials And Methods: The review was conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews. The search strategy was completed in seven electronic databases.

The Probabilistic Price of Life Across Time: Generational and Probabilistic Distance Render a Life Today Worth More Than Ten Tomorrow.

Is the certainty of saving a life today worth more than the less-certain possibility of saving 10 lives tomorrow? In six pre-registered studies with U.S. samples from Prolific ( = 5,095), we employed an intergenerational probability discounting task, discovering people discount the value of life as uncertainty and intergenerational distance from the present increase.