Publications by authors named "B R Ksander"
Bilateral limbal stem cell deficiency (LSCD) is a significant cause of corneal blindness and is more difficult to treat, as compared with unilateral LSCD because no source of autologous limbal stem cells (LSCs) remains in these patients. Thus, bilateral patients could be candidates for treatment with allogeneic LSC transplants that require long-term systemic immunosuppression therapy. Thus, if possible, for the correct candidates, using autologous LSCs could be a preferred treatment.
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- Corneal transparency and avascularity are crucial for clear vision, with a transition to vascularized conjunctiva at the limbus.
- This study identifies a specific sub-population of limbal stromal cells expressing ABCB5, which exhibit mesenchymal stem cell traits and show potential for pluripotency and multi-lineage differentiation.
- ABCB5+ cells demonstrate lower levels of pro-inflammatory and pro-angiogenic factors, suggesting they could help reduce inflammation and neovascularization in the cornea, with potential implications for therapeutic applications elsewhere in the body.
Article Synopsis
- The study aimed to better classify uveal melanoma (UM) cell lines by examining their genetic and expression profiles, particularly focusing on identifying any underlying genetic causes for their behavior.
- Researchers analyzed 14 UM cell lines using techniques like next-generation sequencing and SNP arrays to assess protein and mRNA expression, and to identify genetic variants.
- Results indicated that cell lines Mel285 and Mel290, which do not have typical UM mutations, possess distinct genetic alterations and expression profiles, making them potentially unsuitable for research on therapeutic targets for UM.
Article Synopsis
- The study utilized a mouse model with a mutation that restricts FasL expression to its membrane-bound form to observe CNV development, revealing no significant difference in leakage size when compared to normal mice.
- Interestingly, heterozygous FasL mice experienced less vascular leakage and quicker maturation of new blood vessels, suggesting that the effectiveness of FasL in reducing CNV is linked to its cleavage characteristics and its interaction with specific immune cells.