Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.

The SNF2 family chromatin remodeler HELLS has emerged as an important regulator of cell proliferation, genome stability, and several cancer pathways. Significant upregulation of HELLS has been reported in 33 human cancer types. While HELLS has been implicated in DNA damage response, its function in DNA repair is poorly understood.

De novo generation of colorectal patient educational materials using large language models: Prompt engineering key to improved readability.

Background: Improving patient education has been shown to improve clinical outcomes and reduce disparities, though such efforts can be labor intensive. Large language models may serve as an accessible method to improve patient educational material. The aim of this study was to compare readability between existing educational materials and those generated by large language models.

Injury risk factors and their priority for mitigation in women's netball: a systematic review and Delphi consensus.

This study aimed to establish consensus on injury risk factors in netball via a combined systematic review and Delphi method approach. A systematic search of databases (PubMed, Scopus, MEDLINE, SPORTDiscus and CINAHL) was conducted from inception until June 2023. Twenty-four risk factors were extracted from 17 studies and combined with a three-round Delphi approach to achieve consensus.

Contrasting two versions of the 4-cup 2-item disjunctive syllogism task in great apes.

Chimpanzees excel at inference tasks which require that they search for a single food item from partial information. Yet, when presented with 2-item tasks which test the same inference operation, chimpanzees show a consistent breakdown in performance. Here we test a diverse zoo-housed cohort (n = 24) comprising all 4 great ape species under the classic 4-cup 2-item task, previously administered to children and chimpanzees, and a modified task administered to baboons.