Publications by authors named "B R Heath"
Alphavirus replication is dependent on host cell organelles to facilitate multiple steps of the viral life cycle. New world alphaviruses (NWA) consisting of eastern, western and Venezuelan equine encephalitis viruses are a subgroup of alphaviruses associated with central nervous system disease. Despite differing morbidity and mortality amongst these viruses, all are important human pathogens due to their transmission through viral aerosolization and mosquito transmission.
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- A systematic review was conducted to explore the issue of misdiagnosis in dementia, particularly focusing on rarer subtypes that may struggle more with accurate diagnosis compared to common types like Alzheimer's.
- The review included 20 studies and identified four main themes: factors contributing to misdiagnosis, challenges in the diagnostic process, economic implications, and personal experiences of individuals facing delayed diagnoses.
- There is a critical need for further research on the emotional and monetary effects of dementia misdiagnosis on patients, caregivers, and the healthcare system to improve clinical practices.
Article Synopsis
- - Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems is gaining attention as a better option compared to traditional methods, focusing on recent developments in various therapies.
- - By combining iontophoresis (IP) and electroporation (EP) with MN technology, these systems have shown improved treatment outcomes in areas like vaccine delivery, diabetes management, dermatology, NSAID administration, and more.
- - Despite some challenges regarding safety and technology, ongoing research is looking to enhance these methods for wider use in personalized medicine and innovative therapeutic applications.
Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options. Fucosyl-GM1 (FucGM1) is a glycolipid overexpressed in the majority of SCLC tumors but virtually absent from normal healthy tissues. In this study, we validate a FucGM1-targeting T cell-redirecting bispecific (TCB) antibody for the treatment of SCLC.
View Article and Find Full Text PDFBackground: Only a third of people with dementia receive a diagnosis and post-diagnostic support. An eight session, manualised, modular post-diagnostic support system (New Interventions for Independence in Dementia Study (NIDUS) - family), delivered remotely by non-clinical facilitators is the first scalable intervention to improve personalised goal attainment for people with dementia. It could significantly improve care quality.
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