Symmetric versus asymmetric tibial components: A systematic review of comparative studies.

Background: Total knee arthroplasty (TKA) is a widely performed procedure that significantly enhances patients' quality of life by reducing pain and improving daily function. While the traditional tibial plate design used in TKA has been symmetrical, there has been a recent trend towards using asymmetrical designs. Our study aimed to compare symmetrical and asymmetrical tibial designs, focusing on outcomes related to overhang, malrotation, and tibial coverage.

The Effect of Perceived Social Support on Self-Esteem and Well-Being Among the General Population of Riyadh, Saudi Arabia.

Introduction Perceived social support refers to the subjective assessment of the extent to which an individual feels supported by others. It is a crucial factor that affects a person's mental health, as well as poor self-esteem, which is a common psychiatric complaint correlated with low perceived social support. As the field expands, a better understanding of the correlation between these factors and mental health is important.

Activation of estrogen-related receptor γ by calcium and cadmium.

Objective: Estrogen-related receptor γ (ERRγ) is a metabolic regulator with no identified physiological ligands. This study investigates whether calcium is an ERRγ ligand that mediates the effects of glucagon and whether cadmium, which mimics the effects of calcium, disrupts metabolism through ERRγ.

Method: HepG2, MCF-7, and HEK293T transfected with ERRγ were treated with glucagon, calcium, cadmium, ERRγ agonist, or ERRγ inhibitor.

Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis.

Objective: To predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit.

Design: Individual participant data meta-analysis.

Data Sources: Individual participant data of four cohorts (237 228 pregnancies) from the International Prediction of Pregnancy Complications (IPPIC) network dataset.

Cadmium activation of wild-type and constitutively active estrogen receptor alpha.

The estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of , are associated with acquired resistance to endocrine therapies. We have previously shown that the metalloestrogen calcium activates ERα through an interaction with the LBD of the receptor.