Publications by authors named "B R Greene"
Cytochrome P450s (CYPs) are a superfamily of thiolate-ligated heme metalloenzymes principally responsible for the hydroxylation of unactivated C-H bonds. The lower-axial cysteine is an obligatory and universally conserved residue for the CYP enzyme class. Herein, we challenge this paradigm by systematically identifying non-canonical CYPs (ncCYPs) that do not harbor a cysteine ligand.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how parents of children with cancer receive information about tumor genomic sequencing (TGS) at the time of diagnosis, aiming to improve communication in pediatric oncology.
- Interviews with 20 parents revealed common themes: universal information needs among parents, diverse preferences for information delivery within families, and a desire for standard yet personalized communication.
- The findings suggest that as TGS becomes more integrated into childhood cancer treatment, clinicians might need to adapt their communication strategies to better support parents.
The design and tuning of new ligands is crucial for unlocking new reactivity at transition metal centers. Azophosphines have recently emerged as a new class of 1,3-P,N ligands in ruthenium piano-stool complexes. This work shows that the azophosphine synthesis can tolerate -aryl substituents with strongly electron-donating and electron-withdrawing -R groups and that the nature of this R group can affect the spectroscopic and structural properties of the azophosphines, as measured by NMR spectroscopy, UV-vis spectroscopy, single-crystal X-ray diffraction, and DFT studies.
View Article and Find Full Text PDFArticle Synopsis
- * A study reviewed 46 patients who had completion cholecystectomy after subtotal cholecystectomy, finding that remnant cholecystitis was the main reason for reoperation in 80.4% of cases, with some encountering complications like bile leaks and pancreatitis.
- * The procedure is generally safe and effective, with a high rate of symptom resolution (95.6%), although it can be technically challenging, with a small percentage needing conversion to open surgery.
Article Synopsis
- The study investigates a recent outbreak of monkeypox (mpox) in the Republic of the Congo, which emerged after a notable increase in cases in DR Congo since October 2023.
- Blood, skin, and swabs from suspected mpox cases were collected between January and April 2024, with 31 of 61 samples testing positive for the virus and analyzed using advanced sequencing techniques.
- The phylogenetic analysis revealed two major clusters of monkeypox virus strains, suggesting connections between the current outbreak and earlier sequences from Central Africa, indicating ongoing transmission dynamics in the region.