Publications by authors named "B R Godlewska"
Article Synopsis
- - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks specific treatments, but creatine, which supports cellular energy, was tested as a potential intervention.
- - In a study with 14 ME/CFS participants, those who took creatine for 6 weeks showed increased brain creatine levels, reduced fatigue, improved reaction times on cognitive tests, and enhanced hand-grip strength.
- - The findings suggest that creatine supplementation can benefit ME/CFS patients, prompting the need for further research with placebo controls for solid conclusions.
Background: Depressive disorder is common among haemodialysis patients. The purpose of this study was to explore approaches to diagnosing depression in the context of a real-life setting, with the view of creating practical recommendations. It also aimed to evaluate the prevalence of depression and dementia.
View Article and Find Full Text PDFMajor depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In the COORDINATE-MDD consortium, raw MRI data were shared from international samples ( = 1,384) of medication-free individuals with first-episode and recurrent MDD ( = 685) in a current depressive episode of at least moderate severity, but not treatment-resistant depression, as well as healthy controls ( = 699).
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on the amygdala and dorsal anterior cingulate cortex's role in predicting treatment responses in difficult-to-treat major depressive disorder (MDD) patients, who had not responded to at least two antidepressants.
- - Using fMRI, researchers found that lower activation in the amygdala when responding to sad and happy faces predicted better clinical outcomes in these MDD patients, while the anterior cingulate cortex showed no significant effects.
- - The results suggest that a decreased amygdala response to emotional expressions may be a helpful indicator of symptom improvement in MDD, with heightened anxiety levels diminishing this adaptive response.
Lithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse effects limit its use. We previously reported that a lithium-mimetic agent, ebselen, promoted a positive emotional bias-an indicator of potential antidepressant activity in healthy participants. We therefore aimed to investigate the effects of short-term ebselen treatment on emotional processing and brain neurochemistry in depressed patients with inadequate response to standard antidepressants.
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