Publications by authors named "B R Dorn"
Aims: We aim to evaluate the incidence of atrial fibrillation (AF) in a large real-world cohort of patients implanted with an insertable cardiac monitor (ICM) who had a clinical history of symptomatic heart failure (HF) with reduced or preserved left ventricular ejection fraction (LVEF).
Methods: Patients with an ICM and a history of HF events were identified from the Optum® de-identified Electronic Health Record dataset merged with an ICM device dataset collected during 2007-2021. All ICM-detected AF episodes that were available with ≥30-s of ECG at onset were adjudicated using artificial intelligence (AI model).
Article Synopsis
- * Key allergens evaluated include hyaluronidases from honey bee (Api m 2), European paper wasp (Pol d 2), and yellow jackets (Ves v 2.0101 and Ves v 2.0201), with sensitization rates among patients varying significantly.
- * Results show that individuals primarily sensitized to Api m 2 have minimal cross-reactivity with other venoms, while those sensitized to other allergens may react to Api m 2, emphasizing the importance of identifying the primary allergen for effective
A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10.
J Investig Allergol Clin Immunol
November 2024
Article Synopsis
- Diagnostic variables from insertable cardiac monitors can help identify heart failure (HF) patients at risk, but high-risk alerts must be paired with interventions to improve patient outcomes.
- The ALLEVIATE-HF study involved patients with recent HF events, using a risk score based on various monitor diagnostics to guide intervention protocols, including diuretic uptitration.
- Results showed that the intervention was generally safe, with positive symptom resolution in most cases, indicating the feasibility of tailored medication management based on high-risk alerts.
Article Synopsis
- Underutilization of implantable cardioverter defibrillators (ICDs) in patients who have had a myocardial infarction (MI) remains a problem, especially in areas with low adoption rates, highlighting the need to identify risk factors for sudden cardiac death (SCD).
- In a study of post-MI patients, a 1-year mortality rate was found at 5.9%, with 76.5% of cardiac deaths attributed to SCD, and significant risk factors identified included age, left ventricular ejection fraction, female gender, and regional demographics.
- The study recommends that post-MI patients exhibiting these high-risk characteristics should be referred to specialists for further assessment and potential ICD implantation to help prevent further fatalities.