Publications by authors named "B Prinz"
Article Synopsis
- - In vitro assessments for predicting pharmacokinetic (PK) behavior in biotherapeutics help identify potential issues early in drug discovery, reducing excessive animal testing and optimizing resources.
- - The study highlights the value of integrating in vitro measures, particularly those assessing nonspecific interactions and FcRn interactions, as they correlate well with drug clearance in a specific mouse model.
- - A computational method is proposed to enhance the correlation to PK by combining various in vitro measurements with multivariate regression, allowing for better prioritization of drug candidates with ideal PK profiles.
Purpose: The aim of this investigation was to assess alterations of pulmonary oxygen uptake (V˙O2) and muscle deoxygenation on-kinetics during heavy-intensity cycling in youth cyclists over a period of 15 months.
Methods: Eleven cyclists (initial age, 14.3 [1.
Alterations of aerobic fitness and muscle deoxygenation during a ramp incremental exercise test (GXT) were assessed on two occasions within a time-frame of 2.9 ± 0.1y in competitive youth cyclists.
View Article and Find Full Text PDFPurpose: The main purpose of the current study was to investigate the dynamic adjustment of pulmonary oxygen uptake ( O) in response to moderate-intensity cycling on three occasions within 15 months in competitive youth cyclists. Furthermore, the muscle Δdeoxy[heme] on-kinetics and the Δdeoxy[heme]-to- O ratio were modeled to examine possible mechanistic basis regulating pulmonary O on-kinetics.
Methods: Eleven cyclists (initial age, 14.
Background: Subcutaneous venom immunotherapy (VIT) represents an effective treatment against bee venom allergy. However, it involves long treatment times, high costs, and the risk of adverse events (AEs). Shorter, safer, and cheaper treatment options are therefore pursued.
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