Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells.

Liver fibrosis is a critical liver disease that can progress to more severe manifestations, such as cirrhosis, yet no effective targeted therapies are available. Here, we identify that ATF4, a master transcription factor in ER stress response, promotes liver fibrosis by facilitating a stress response-independent epigenetic program in hepatic stellate cells (HSCs). Unlike its canonical role in regulating UPR genes during ER stress, ATF4 activates epithelial-mesenchymal transition (EMT) gene transcription under fibrogenic conditions.

Subnano AlO Coatings for Kinetics and Stability Optimization of LiNiCoMnO via O-Based Atomic Layer Deposition.

The Ni-rich LiNiCoMnO cathode (NCM, ≥ 0.6) suffers rapid capacity decay due to serious surface degradations from the corrosion of the electrolyte. The processes of the HO- and O-based AlO atomic layer deposition (ALD) on the single-crystal LiNiCoMnO (NCM83) are investigated by measurements to understand the mechanism of their different impacts on the electrochemical performance of NCM83.

Predicting microbe-disease associations via graph neural network and contrastive learning.

In the contemporary field of life sciences, researchers have gradually recognized the critical role of microbes in maintaining human health. However, traditional biological experimental methods for validating the association between microbes and diseases are both time-consuming and costly. Therefore, developing effective computational methods to predict potential associations between microbes and diseases is an important and urgent task.