Toward Cytogenomics: Technical Assessment of Long-Read Nanopore Whole-Genome Sequencing for Detecting Large Chromosomal Alterations in Mantle Cell Lymphoma.

The current advances and success of next-generation sequencing hold the potential for the transition of cancer cytogenetics toward comprehensive cytogenomics. However, the conventional use of short reads impedes the resolution of chromosomal aberrations. Thus, this study evaluated the detection and reproducibility of extensive copy number alterations and chromosomal translocations using long-read Oxford Nanopore Technologies whole-genome sequencing compared with short-read Illumina sequencing.

Experimental and numerical investigations of arc plasma expansion in an industrial vacuum arc remelting (VAR) process.

In the present study, we investigate arc plasma expansion in an industrial vacuum arc remelting (VAR) process using experimental and numerical tools. Stainless steel is the alloy of interest for the electrode (cathode) and ingot (anode). During the operation of the VAR process, behaviors of cathode spots and plasma arc were captured using the high-speed camera (Phantom v2512).

The real-world outcomes of multiple myeloma patients treated with daratumumab.

Unlabelled: Most patients cannot be included in randomized clinical trials. We report real-world outcomes of all Danish patients with multiple myeloma (MM) treated with daratumumab-based regimens until 1 January 2019.

Methods: Information of 635 patients treated with daratumumab was collected retrospectively and included lines of therapy (LOT), hematologic responses according to the International Myeloma Working Group recommendations, time to next treatment (TNT) and the cause of discontinuation of treatment.