Publications by authors named "B Ponder"

Article Synopsis
  • The study develops a new method to identify genetic variants that increase breast cancer risk by focusing on variants in gene regulatory regions, using genome-wide association studies (GWAS) as a basis.
  • Through analysis of microarray data from normal breast tissue, the researchers identified over 54,000 differential allelic expression QTLs (daeQTLs) linked to breast cancer risk, mapping these to relevant genes and loci.
  • The findings highlight the connection between risk-related genetic variants and gene expression regulation, identifying candidate causal variants at the 5q14.1 locus that may influence breast cancer risk through alternative transcription mechanisms.
View Article and Find Full Text PDF

Background: Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of tobacco smoke has long been established. More than 50% of all smoking-related lung cancers occur in former smokers, 40% of which occur more than 15 years after smoking cessation.

View Article and Find Full Text PDF

Porous high-density polyethylene (PHDPE) has been used since the 1990s as an alternative to autologous grafts. Implant extrusion is a rare but well-known complication of PHDPE and other alloplastic implants. This article discusses the case of PHDPE implant extrusion in a 69-year-old man with unsuccessful previous alar batten graft placement for internal nasal valve insufficiency.

View Article and Find Full Text PDF

Trichofolliculoma is a rare tumor that arises from immature hair follicular tissue. In this report, we present the case of a 51-year-old man with a trichofolliculoma in the left external auditory canal. Uniquely, there was no prior trauma in this patient, despite previous trauma being hypothesized in the etiology of this tumor.

View Article and Find Full Text PDF

Reactive hyperplasia is a phenomenon responsible for exophytic lesions in the oral cavity, and may appear to be suspicious, especially in patients who have a significant history of malignancy. Here, we present a case of reactive hyperplasia mimicking recurrence in a patient who was previously treated for tonsillar carcinoma. Physicians who commonly see patients with oral lesions, particularly oral surgeons and otolaryngologists, should be cognizant of the unusual presentation of these lesions as they may mimic the physical characteristics of recurrence.

View Article and Find Full Text PDF