Multidisciplinary design optimisation of lattice-based battery housing for electric vehicles.

Batteries with high energy densities become essential with the increased uptake of electric vehicles. Battery housing, a protective casing encapsulating the battery, must fulfil competing engineering requirements of high stiffness and effective thermal management whilst being lightweight. In this study, a graded lattice design framework is developed based on topology optimisation to effectively tackle the multidisciplinary objectives associated with battery housing.

Flavonoids activate wild-type p53.

Flavonoids are diphenyl propanoids widely distributed in edible plants. They play a dual role in mutagenesis and carcinogenesis. Some of them act as anticarcinogens or inhibit the growth of tumour cells, whereas others act as cocarcinogens, are mutagenic or able to induce DNA damage.

Nitric oxide production by cells isolated from regenerating rat liver.

Nitric oxide (NO) production by cells of the regenerating liver was estimated from the amount of nitrite accumulated during 24 h in the culture media of hepatocytes, Kupffer cells and sinusoidal endothelial cells isolated at different times after partial hepatectomy (PHE). The time course of NO production was compared with the course of the proliferating activity of the same cells. During the time when liver cells pass through their first cell cycles, hepatocytes were the main producers of NO in the liver.

Nuclear accumulation of p53 in response to treatment with DNA-damaging agents.

A number of agents which damage DNA also trigger the nuclear accumulation of the tumor suppressor protein p53. Here we show the correlation with different p53 detection methods. As an example we investigated the effects of the cancer therapy drug mitomycin C on different mammalian cell lines.