[The effect of using furosemide in selective adrenergic alpha 1-receptor stimulation and alpha 1-receptor blockade].

Experiments were carried out on male white rats of Wistar strain, placed in metabolic cages in a room with artificial light and dark at 12-hour periods. Furosemide in a dose of 4 mg/kg was used intraperitoneally singly or after pretreatment with methoxamine in a dose of micrograms/kg or prazosin in a dose of 0.2 mg/kg.

[A compartment analysis of the significance of extracellular fluid volume for body fluid dynamics].

The curve of a reduction in plasma concentration of the indicator substance creatinine for a period of 120 to 240 min was investigated after single intravenous administration of creatinine in a dose of 150 mg/kg on dogs. A model for two compartment distribution of the indicator substance was used as the first compartment was intravasal, but the second--interstitial space of body fluids. The following parameters were estimated: renal clearance, volume of distribution, glomerular filtration, intercompartment clearance and velocity constants of transport between the two compartments.