Correlation of the femoral pulse and mesenteric perfusion pressure in acute aortic dissection.

Background: Visceral malperfusion is a serious complication of acute aortic dissection. Currently, diagnosis relies on signs of end-organ failure, which may be clinically obscure and delay crucial treatment.

Objective: The aim was to investigate external iliac (IA) and superior mesenteric artery (SMA) pressures in cases where both vessels originate exclusively from the true lumen to develop and validate a novel early indicator of visceral malperfusion.

Disease diagnostics using machine learning of B cell and T cell receptor sequences.

Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system's own record of antigen exposures encoded by receptors on B cells and T cells. We analyzed immune receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis, an interpretive framework to screen for multiple illnesses simultaneously or precisely test for one condition. This approach detects specific infections, autoimmune disorders, vaccine responses, and disease severity differences.

Rift Valley fever virus remains infectious in milk stored in a wide range of temperatures.

Background: Rift Valley fever virus (RVFV) is a zoonotic arbovirus widely distributed across Africa and the Arabian Peninsula, which causes devastating epidemics affecting humans as well as ruminant livestock. The epidemiology of RVFV is difficult to disentangle, as the virus is transmitted to humans via mosquitos or direct contact with infected animals. Among these direct exposures are milking ruminants and drinking fresh milk which have been firmly established as risk factors for RVFV exposure.