Publications by authors named "B Pillot"
The environmental and multi-sectoral challenges faced by small islands requires consideration of sustainability issues. The sustainability challenges in these regions involve in particular the achievement of a greater autonomy through the development of local resources. This is a complex system that encompasses interconnections between the resources available and the land use.
View Article and Find Full Text PDFBackground: The aim of our study was to test different anesthetic mixtures in order to identify the most suitable one for a surgical cardiac ischemia-reperfusion model in mice.
Methods: 1) Sixty four mice were submitted to one of the 6 combinations of ketamine or alfaxalone associated to xylazine, medetomidine or midazolam. Depth and quality of anesthesia were evaluated via 5 reflex scores.
Article Synopsis
- The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
- Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
- The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
Article Synopsis
- Myocardial infarction (MI) causes heart muscle damage due to blocked blood flow, leading to the production of reactive oxygen species and a redox imbalance, with myoglobin playing a key role in this process.
- The study introduces a new imaging method that uses advanced techniques to examine the oxidation-reduction states of myoglobin in heart tissue after MI, revealing how myoglobin's fluorescence can indicate the state of the myocardium.
- Findings show that the spectral properties of myoglobin in infarcted heart tissue correlate with infarct size, suggesting myoglobin's redox state could be a valuable biomarker for assessing MI severity in its early stages.
Cyclosporine A (CsA) preconditioning is known to target mitochondrial permeability transition pore and protect renal function after ischemia reperfusion (IR). The upregulation of heat-shock protein 70 (Hsp70) expression after CsA injection is thought to be associated with renal protection. The aim of this study was to test the effect of Hsp70 expression on kidney and mitochondria functions after IR.
View Article and Find Full Text PDF