Publications by authors named "B Pijlman"
Article Synopsis
- In a study about endometrial cancer, doctors looked at how preoperative health issues like anemia (low red blood cells), thrombocytosis (high platelets), and leucocytosis (high white blood cells) affect patient survival and treatment response.
- They checked medical data from 894 patients from 10 hospitals over about 4.5 years and found that anemia and thrombocytosis linked to higher risk levels for the disease.
- The results showed that anemia made survival rates worse, especially for patients getting radiation therapy, meaning those with anemia had a harder time fighting the cancer.
Article Synopsis
- Patients with high-grade endometrial carcinoma (EC) have a higher likelihood of tumor spread and lymph node metastasis (LNM), with preoperative imaging and CA125 levels aiding in their assessment.
- A study involving 333 high-grade EC patients found that elevated CA125 levels significantly correlated with advanced disease stages and poorer survival outcomes.
- Logistic regression analysis indicated that elevated CA125, non-endometrioid histology, deep myometrial invasion, and cervical involvement are strong predictors of LNM, while CT findings alone were less predictive.
Background: Advanced low-grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However, only a subgroup of patients respond to AHT, and this response cannot be adequately predicted by currently used immunohistochemistry (IHC).
View Article and Find Full Text PDFBackground: Opportunistic salpingectomy comprises additional bilateral salpingectomy during abdominal surgery as a prophylactic method to reduce the risk of ovarian cancer. However, opportunistic salpingectomy may potentially damage (micro)blood circulation to the ovaries, resulting in earlier onset of menopause.
Primary Objective: To evaluate the long-term effects of opportunistic salpingectomy on the onset of menopause in women who underwent sterilization through salpingectomy compared with a control group who underwent sterilization by tubal ligation or no surgery at all.
Preoperative histopathological classification determines the primary surgical approach in endometrial carcinoma (EC) patients but has only moderate agreement between preoperative and postoperative diagnosis. The aim of the PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study is to determine whether histopathological assessment and a small panel of diagnostic biomarkers decreases discrepancies between preoperative and postoperative diagnosis in EC. Preoperative endometrial tissue of 378 included patients with EC was stained with 15 different antibodies.
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