Publications by authors named "B Philosophe"
Background: Machine perfusion (MP) for liver transplantation has become more widespread in the United States, but national studies on this growing practice are lacking. We investigated national use and outcomes of MP for liver transplantation.
Methods: Adult (≥18 y) liver recipients transplanted between January 1, 2016 and September 30, 2023 in the United Network for Organ Sharing database were included.
Article Synopsis
- A study at Johns Hopkins Hospital compared outcomes of patients who received neoadjuvant immunotherapy before surgery with those who had upfront resection; 36 of the 92 patients received the immunotherapy.
- The results showed that patients who underwent neoadjuvant immunotherapy had similar resection margins and recurrence-free survival rates compared to those who had upfront surgery, suggesting that this approach might help high-risk patients achieve comparable outcomes.
Article Synopsis
- The study examined livers from 45 patients with severe alcoholic hepatitis (SAH) and found high levels of IgG and IgA antibodies linked to liver cell damage.
- Antibodies extracted from SAH livers showed the ability to kill liver cells and recognized specific human proteins not found in healthy livers or livers affected by other diseases.
- The research identified cross-reacting autoantibodies in SAH that target common cellular components, which is unique compared to antibodies from livers with other conditions.
Article Synopsis
- Health-related quality of life (HRQoL) is an important measure for patients with hepatocellular carcinoma (HCC) and serves as a prognostic indicator and clinical endpoint.
- This study explored the relationship between BCLC stage, Child-Pugh score, and ECOG performance status on HRQoL, using the FACT-Hep questionnaire for assessment.
- Findings revealed that while BCLC stages did not significantly correlate with HRQoL, patients with worse liver function (CP B) experienced a notable decline in quality of life, highlighting the need for further research on the effects of early supportive care interventions.
Background: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had unprecedented effects on society and modern healthcare. In liver transplantation, uncertainty regarding the safety of performing transplants during the early stage of the pandemic resulted in increased waitlist mortality. Additionally, concerns about disease transmission led to avoidance of deceased donors with COVID-19 infections.
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