Publications by authors named "B Perlman"
Article Synopsis
- Advances in high-resolution mapping have revealed complex structures formed by enhancers and promoters, known as enhancer-promoter hubs or cliques, which play a role in gene regulation.
- This study identifies enhancer-promoter hubs in breast cancer, lymphoma, and leukemia, highlighting their formation at important oncogenes and transcription factors that could drive cancer development.
- The research also shows that changes in these hubs are linked to shifts in gene expression related to resistance against targeted cancer therapies, indicating their potential impact on both oncogenesis and treatment outcomes.
Introduction: Cervical cytology remains a critical screening tool for cervical cancer. While various factors can influence cytology quality, the effect of lubricant type used during specimen collection has been previously studied with inconclusive results. This study aimed to evaluate the impact of surgical lubricant on cervical cytology results and elucidate risk factors associated with unsatisfactory results.
View Article and Find Full Text PDFIn three studies, we examined the effect of shifting from a negative to a positive inference for a negative personal event, on mood, state rumination, and next-day inferences, and assessed whether trait brooding moderates these effects. Participants described a personal event and made two inferences for it. Studies 1 and 2 showed that instructing participants to shift from a negative to a positive inference, improved mood and decreased state rumination, compared to a no-shift condition.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers systematically mapped these hubs in breast cancer, lymphoma, and leukemia, discovering that they often cluster around key oncogenes and transcription factors linked to cancer development.
- * The study also revealed that changes in these enhancer-promoter hubs are associated with transcriptional shifts that contribute to drug resistance in specific blood cancers, indicating their dynamic nature and potential influence on cancer treatment outcomes.
Background: The effects of spinal versus general anesthesia on long-term outcomes have not been well studied. This study tested the hypothesis that spinal anesthesia is associated with better long-term survival and functional recovery than general anesthesia.
Methods: A prespecified analysis was conducted of long-term outcomes of a completed randomized superiority trial that compared spinal anesthesia versus general anesthesia for hip fracture repair.