Publications by authors named "B Pecavar"
HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013.
Acta Dermatovenerol Alp Pannonica Adriat
September 2023
Introduction: Disease progression, drug resistance mutations, and treatment strategies may vary by HIV-1 subtype. This study determined HIV-1 subtypes circulating in Slovenia, a Central European country with an HIV-1 epidemic driven by men who have sex with men, focusing on molecular epidemiology of non-B subtypes.
Methods: A total of 367 HIV-1 sequences were included.
Prevalence of HIV in Slovenia is low, and men who have sex with men (MSM) have the highest risk for infection. Rates of enrolment into HIV care, initiation of antiretroviral therapy and reaching an undetectable viral load in HIV-infected patients are very high. Prevention of HIV infection for MSM with PrEP is not formally available in Slovenia.
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- The third Slovenian national survey on healthcare-associated infections (HAIs) aimed to estimate HAI prevalence and identify associated factors in acute care hospitals.
- In a one-day study with 5,743 patients, 6.6% had at least one HAI, with pneumonia being the most common type, especially prevalent in ICUs where the rate was 30.6%.
- Key risk factors for HAIs included the use of central and peripheral vascular catheters and urinary catheters, highlighting the need for effective prevention and control measures in healthcare settings.
HIV-positive individuals that have a detected transmitted drug resistance (TDR) at baseline have a higher risk of virological failure with antiretroviral therapy (ART). This study offers an update on the prevalence of TDR in Slovenia, looks for onward transmission of TDR, and reassesses the need for baseline drug resistance testing. Blinded questionnaires and partial pol sequences were obtained from 54.
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- Vascular graft infections (VGIs) pose significant health risks, and improving microbial identification is crucial for effective treatment.
- A study analyzed 22 patients with VGIs, using sonication and culture techniques to identify causative organisms; success rates for identifying pathogens were high.
- The findings suggest that sonicate fluid culture and broad-range PCR can enhance the effectiveness of antimicrobial treatment, highlighting the need for further research on antibiotic timing before graft removal.