Publications by authors named "B Paul Carney"
Burn injury results in hypercoagulability and an increased venous thromboembolism risk. However, the most effective chemoprophylaxis for burn-injured patients has yet to be elucidated. Therefore, this study aims to identify the safety and efficacy of a burn center's venous thromboembolism protocol modification which increased the dose of enoxaparin from 40mg daily to 40mg twice daily with peak anti-Xa level adjustments.
View Article and Find Full Text PDFArticle Synopsis
- Cutaneous lupus erythematosus (CLE) is a skin-related manifestation of lupus erythematosus, classified into subtypes (acute, subacute, chronic) based on clinical characteristics and lab findings.
- Traditional treatments include topical corticosteroids and antimalarial drugs, but new immunomodulatory therapies, particularly Janus kinase (JAK) inhibitors, are emerging options.
- The review highlights the importance of understanding the JAK/STAT signaling pathway in CLE management and calls for more research on the safety and effectiveness of JAK inhibitors for autoimmune disease treatment.
Article Synopsis
- ECMO usage is increasing, but determining which patients will benefit the most is challenging, making risk stratification crucial.
- This study evaluated the impact of two biomarkers, SDC-1 and soluble thrombomodulin (sTM), on mortality rates in patients on venoarterial ECMO.
- Results showed that higher levels of sTM significantly correlate with increased mortality risk, while SDC-1 levels are marginally predictive; these findings suggest that incorporating these biomarkers could enhance existing scoring systems for better patient assessment.
Introduction: Literature examining the impact of obesity on burn injury remains mixed. Previous examination of the National Burn Repository, now the BCQP, in obesity-related burn research is limited. The aim of this work was to provide an assessment of the BCQP dataset to examine the effect of obesity on burn-related outcomes.
View Article and Find Full Text PDF