Publications by authors named "B Pastor-Diez"

Article Synopsis
  • Late postnatal steroids, specifically betamethasone (BTM), are given to extremely preterm infants to help them transition from invasive ventilation and reduce the risk of developing bronchopulmonary dysplasia (BPD), while also addressing patent ductus arteriosus (PDA).
  • In a study of 51 infants born before 29 weeks gestation, most were successfully extubated after receiving BTM, with nearly all showing closure or improved PDA status post-treatment.
  • Although BTM treatment resulted in some transient side effects like hypertension and hyperglycemia, the findings suggest it may reduce the need for more invasive surgical options in this vulnerable population.
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Aim: The aim of this French study was to determine the neonatal morbidity, mortality and neurodevelopmental outcomes when infants born at the limit of viability reached 2 years of corrected age. We then compared the results with national and international cohorts.

Methods: This study focused on 294 French infants born from 22 to 25 weeks of gestation in a single tertiary perinatal centre from January 2010 to December 2019.

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Background: A new medical device was developed for multi-infusion in neonatal intensive care units (NICUs) with the aim of addressing issues related to drug incompatibilities and central-line-associated bloodstream infections (CLABSIs).

Aim: To assess the cost-effectiveness of implementing this new perfusion system in an NICU setting.

Methods: This single-centre, observational study was conducted in all infants admitted to the NICU within 3 days of birth, and who required a central venous line, to evaluate the cost and effectiveness before (2019) and after (2020) implementation of the new perfusion system.

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The administration of dexamethasone has been associated with suboptimal neurodevelopment. We aimed to compare the development of extremely premature infants treated or not with alternatives to dexamethasone: betamethasone, hydrocortisone hemisuccinate. This retrospective cohort study included infants born before 29 weeks of gestational age, treated or not with late (day ≥ 7) postnatal steroids (betamethasone, hydrocortisone hemisuccinate).

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Background: Central-venous-line-associated bloodstream infection (CLABSI) is a significant cause of morbidity and mortality in preterm infants. As there is large variation in the reported effect of multi-modal preventive strategies, it could be relevant to propose new additional strategies.

Aim: To assess the impact of a new perfusion system on CLABSI rate.

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