["Aftercare and psychiatric disorders, the experience of the Repairs association! 44].

Young adults leaving child protection services face difficulties in accessing housing and rights, but above all social isolation, due to a lack of family resources and friendships as a result of an institutional path strewn with breakdowns. For those with mental health problems, long-term investment in psychiatric care is more than complex. Repairs! 44 strives to change mentalities by drawing on the experiential expertise of its volunteers, so that public opinion becomes aware of the multitude of obstacles these young people face throughout their lives, and aims to make their rights more accessible.

Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study.

Cannabis use may impair cognitive function (CF) differently in men and women, due to sex-specific differences in neurobiological mechanisms and environmental risk factors. Assess sex differences in the association between cumulative exposure to cannabis and cognitive performance in middle age. We studied participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, including Black and White men and women 18-30 years old at baseline followed over 30 years.

NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells.

Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion of patients with GPS develop autoimmunity through an unknown mechanism, which might be related to the proteins NBEAL2 interacts with, specifically in immune cells. Here we show a comprehensive interactome of NBEAL2 in primary T cells, based on mass spectrometry identification of altogether 74 protein association partners.

A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.

Cells receive, and adjust to, various stimuli, which function as part of complex microenvironments forming their "context". The possibility that a given context impacts the response to a given stimulus defines "context-dependency" and it explains large parts of the functional variability of physiopathological and pharmacological stimuli. Currently, there is no framework to analyze and quantify context-dependency over multiple contexts and cellular response outputs.