Publications by authors named "B Parisi"
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that accumulation of primary conjugated and secondary bile acids (BAs) are metabolic features of human hepatocellular carcinoma and experimental liver cancer models. Inhibiting conjugated BA synthesis in hepatocytes through deletion of the BA-conjugating enzyme bile acid-CoA:amino acid -acyltransferase (BAAT) enhanced tumor-specific T cell responses, reduced tumor growth, and sensitized tumors to anti-programmed cell death protein 1 (anti-PD-1) immunotherapy.
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- Potato (Solanum tuberosum L.) is vital for diverse cropping systems due to its adaptability, yield, and nutritional benefits, especially through breeding for health-promoting compounds like anthocyanins.
- Increased anthocyanin levels in potato varieties, specifically the purple-fleshed Bleuet and red-fleshed DAR170, demonstrate greater resilience to drought stress compared to the non-pigmented Monalisa, indicating that anthocyanins may trigger a shift from growth to stress tolerance.
- The study supports a regulatory relationship between the miR156-SPL9 module and anthocyanin biosynthesis, highlighting their role in the development and drought response of different potato genotypes.
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- Neurons rely on autophagy, a process that recycles damaged proteins and organelles, to maintain cellular health and function over their long lifespan, particularly in the face of challenges like starvation.
- Research shows that a neuron-specific protein called APache plays a critical role in autophagy by helping transport autophagosomes back to the cell body, affecting synaptic health.
- Silencing APache disrupts this transport, leading to an accumulation of autophagosomes at synapses which may contribute to early neurodegenerative issues linked to impaired autophagy.
The RAS-MAPK-pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular differentiation. Here we implement the C2C12 myoblast cell line to systematically study the effect of Ras mutants and Ras-pathway drugs on differentiation.
View Article and Find Full Text PDFDietary restriction, such as low glycemic index diet (LGID), have been successfully used to treat drug-resistant epilepsy. However, if such diet could also counteract antiepileptogenesis is still unclear. Here, we investigated whether the administration of LGID during the latent pre-epileptic period, prevents or delays the appearance of the overt epileptic phenotype.
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