Publications by authors named "B Panfil"

The effects of 5-fluorouracil (5-FU) on DNA synthesis, mitotic index and cell composition of mouse spleens after 6 Gy X rays irradiation of mice and syngenic bone marrow transplantation were investigated. One dose of 5-FU (100 mg/kg body weight) administered 16 hrs after bone marrow transplantation reduced mitotic index and development of bone marrow grafts, but did not inhibit incorporation of 3H-thymidine into DNA. It correlates with high thymidylate synthase activity previously noted in the same model.

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The effects of 5-fluorouracil (5-FU) on thymidylate synthase activity and development of myelopoietic tissue in spleens of recipient mice grafted with bone marrow collected from untreated mice, treated with phenylhydrazine or phenylhydrazine and 5-FU were investigated. One dose of 5-FU (100 mg/kg body weight) reduced development of bone marrow grafts from all donors. The activity of thymidylate synthase sharply declined during the first three days after irradiation irrespective of bone marrow transplantation.

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