Publications by authors named "B Pajak"
Glucose metabolism is a crucial biological pathway maintaining the activation of extra- and intracellular signaling pathways involved in the immune response. Immune cell stimulation via various environmental factors results in their activation and metabolic reprogramming to aerobic glycolysis. Different immune cells exhibit cell-type-specific metabolic patterns when performing their biological functions.
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- The study investigates how painful temporomandibular disorders (TMDs) and myopia affect muscle activity, sensitivity, and sleep quality in individuals, classifying participants into four distinct groups based on their conditions.
- Results indicate that those with both myopia and TMDs experience increased muscle tenderness, altered bioelectrical activity in their muscles, and poorer sleep quality compared to other groups.
- The findings suggest a link between visual issues and muscle function, highlighting the need for further research on how refractive errors could impact muscle behavior during similar studies.
Accommodation is a phenomenon of the eyeball, which consists of adapting to view objects at different distances. The main aim of this study is to evaluate the effect of accommodations on the musculoskeletal system in myopic and emmetropic subjects. To date, the effect of accommodative paralysis on the musculoskeletal system has not been studied.
View Article and Find Full Text PDF2-Deoxy-d-glucose (2-DG), a compound known to interfere with d-glucose and d-mannose metabolism, has been tested as a potential anticancer and antiviral agent. Preclinical and clinical studies focused on 2-DG have highlighted several limitations related to 2-DG drug-like properties, such as poor pharmacokinetic properties. To overcome this problem, we proposed design and synthesis of novel 2-DG prodrugs that subsequently could be tested using a variety of biochemical and molecular methods.
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- The research aimed to determine if visual input affects the electromyographic activity of certain muscles involved in chewing and neck support in emmetropic Caucasian individuals, differentiated by gender.
- Involved 50 emmetropic Caucasian subjects, analyzing the temporalis, masseter, digastric, and sternocleidomastoid muscles during both resting and functional activities.
- Results showed no significant differences in muscle activity patterns with open versus closed eyes for both genders, except for minor differences during clenching in females, indicating visual input doesn’t substantially affect these muscle activities.