Hepatozoon canis infection in a litter of Dalmatian dogs.

Infection with Hepatozoon canis is described in a litter of seven Dalmatians. Four littermates were presented with concurrent hepatozoonosis and parvoviral enteritis and the remaining three puppies were parasitemic with H. canis with no other concurrent disease.

Hepatozoon canis: the prevalence of antibodies and gametocytes in dogs in Israel.

A survey for the prevalence of antibodies to Hepatozoon canis and for intraneutrophilic H. canis gametocytes in the peripheral blood neutrophils of dogs in Israel showed that 33.1% were seropositive, while only 1% of the dogs sampled had detectable parasites in their blood smears.

Hepatozoon canis infection in two dogs.

Infection of 60 to 90% of neutrophils with the protozoa, Hepatozoon canis, was detected in 2 dogs. Clinical signs included lethargy, anorexia, and weight loss. Both dogs had severe anemia, leukocytosis, and thrombocytopenia as well as hypoalbuminemia, hyperglobulinemia, and high activities of serum alkaline phosphatase and creatine kinase.

[Alder anomaly accompanied by myeloperoxidase mutation].

A third form of the Alder anomaly is described in which the peroxidase of neutrophilic polymorphonuclear cells (PNC) is resistant to fixation in methanol, a necessary step in the May-Grunwald Giemsa staining procedure. This property of the abnormal cells is similar to that of eosinophils, rather than normal PNC. However, the PNC in this form of the condition also have the abnormal granulation typical of the other forms of the anomaly.

Alder anomaly accompanied by a mutation of the myeloperoxidase structural gene.

In this paper, a third form of Alder anomaly is described. In addition to the morphological changes which are characteristic of this anomaly, the peroxidase of the neutrophil polymorphonuclear leukocytes (NPNL) is abnormal in its properties. It is resistant to the fixation step in the May-Grünwald Giemsa procedure and is similar, therefore, to the eosinophil peroxidase.