ABC-type salt tolerance transporter genes are abundant and mutually shared among the microorganisms of the hypersaline Sambhar Lake.

To fish-out novel salt-tolerance genes, metagenomic DNA of moderately saline sediments of India's largest hypersaline Sambhar Lake was cloned in fosmid. Two functionally-picked clones helped the Escherichia coli host to tolerate 0.6 M NaCl.

Maternal exposure to chronic, low-dose nonylphenol in zebrafish: Disruption of ovarian health, reproductive function, and embryogenesis.

Nonylphenol (NP), a non-ionic surfactant and potent endocrine disruptor, is known for its environmental persistence, biotic accumulation potential and toxicity. Nonetheless, mechanisms underlying NP modulation of female fertility with potential impact on embryogenesis in the unexposed offspring remain elusive. This study investigates the effects and toxic mechanisms of maternal exposure to NP at varying concentrations (50 and 100 μg/L) on zebrafish (Danio rerio), specifically focusing on ovarian health, reproductive parameters, and early developmental potential in the F1 generation.

Mindin/spondin-2 regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis.

Fibrosis results from excessive extracellular matrix (ECM) deposition, causing tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However, it remains unclear if the same fibroblast performs all of the processes that fall under the umbrella term of "activation".

[General dental practitioners' and dental hygienists' perspectives on the guideline for periodontal screening, diagnostics, and treatment in general practice].

In January 2021, the guideline 'Periodontal screening, diagnosis, and treatment in general practice' was introduced as a successor to the so-called paro protocol. Simultaneously, the Dutch Periodontal Screening Index was replaced by the Periodic Periodontal Screening. The experiences of general dental practitioners and dental hygienists with the new guideline were evaluated in the autumn of 2022.