Publications by authors named "B P Sperry"
Importance: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cardiomyopathy that commonly presents with concomitant chronic kidney disease. Chronic kidney dysfunction is associated with worse outcomes, but the prognostic value of changes in kidney function over time has yet to be defined.
Objective: To assess the prognostic importance of a decline in estimated glomerular filtration rate (eGFR) in a large cohort of patients with ATTR-CM.
Article Synopsis
- The HELIOS-B trial is the first randomized study testing a gene silencing treatment, vutrisiran, for transthyretin cardiac amyloidosis (ATTR-CM) against a placebo.
- Vutrisiran showed a 28% reduction in all-cause mortality and recurrent cardiovascular events, along with significant improvements in patient-reported outcomes like the 6-minute walk test and quality of life metrics.
- Both treatment and control groups had similar rates of discontinuation and adverse events, indicating vutrisiran is well tolerated among patients.
Purpose Of Review: This article summarizes findings seen in various cardiomyopathies on myocardial perfusion imaging (MPI) with positron emission tomography (PET).
Recent Findings: MPI is the cornerstone for evaluation of coronary ischemia, and technological advancements have yielded improved imaging quality and reduction in radiation exposure, particularly with PET. Multi-specialty guidelines and appropriate use criteria provide guidance on utilization of PET MPI in various scenarios related to evaluation of chest pain, new onset cardiomyopathy, and other scenarios where coronary ischemia should be assessed.
Objectives: To evaluate the effectiveness of cervical transforaminal epidural steroid injection (CTFESI) for the treatment of unilateral cervical radicular pain.
Design: Single-group prospective cohort study.
Methods: Outcomes included ≥50% reductions in Numeric Rating Scale (NRS) for arm pain, ≥30% Neck Disability Index (NDI-5) improvement, health-related quality of life (EQ-5D), global improvement (PGIC), personal goal achievement (COMBI), Chronic Pain Sleep Index (CPSI), and healthcare utilization at one, three, six, and 12 months.