Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.

Lipoprotein(a) (Lp(a)), an independent, causal cardiovascular risk factor, is a lipoprotein particle that is formed by the interaction of a low-density lipoprotein (LDL) particle and apolipoprotein(a) (apo(a)). Apo(a) first binds to lysine residues of apolipoprotein B-100 (apoB-100) on LDL through the Kringle IV (K) 7 and 8 domains, before a disulfide bond forms between apo(a) and apoB-100 to create Lp(a) (refs. ).

Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.

in vivo

Working at the interface between science and culture: The enablers and barriers to individual placement and support implementation in Aotearoa/New Zealand.

Objective: To identify the factors that help and hinder the implementation of individual placement and support (IPS) practices in the Aotearoa/New Zealand (Aotearoa/NZ) context.

Methods: An examination of the conceptual and empirical literature on IPS implementation in Aotearoa/NZ and a prospective cohort study of people with mental illnesses and/or methamphetamine addiction participating in a newly established IPS program.

Results: IPS programs have been operating in Aotearoa/NZ for more than 10 years, but coverage across the country is patchy and access inequitable.

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay.

Background The Na1.7 subtype of voltage-gated sodium channels is specifically expressed in sensory and sympathetic ganglia neurons where it plays an important role in the generation and transmission of information related to pain sensation. Human loss or gain-of-function mutations in the gene encoding Na1.

The therapeutic potential of targeting the K1.1 (renal outer medullary K) channel.

K1.1 (renal outer medullary K) channels are potassium channels expressed almost exclusively in the kidney and play a role in the body's electrolyte and water balance. Potassium efflux through K1.