Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains.

Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the link between cholesterol homeostasis and mutant APC-KRas-associated colorectal tumorigenesis remains to be established. Thus, we investigated the impact of Apc-Kras on (i) colonocyte plasma membrane cholesterol homeostasis, order, and receptor nanoclustering, (ii) colonocyte cell proliferation, and (iii) whether these effects are modulated by select membrane active dietaries (MADs).

Catalytic Lysine745 targeting strategy in fourth-generation EGFR tyrosine kinase inhibitors to address C797S mutation resistance.

Overcoming resistance to third-generation tyrosine kinase inhibitors (TKIs) such as Osimertinib, particularly due to the emergence of the C797S mutation, remains a key challenge in non-small cell lung cancer (NSCLC) therapy. This review highlights recent advancements in the development of fourth-generation EGFR inhibitors that specifically target the catalytic Lys745 residue, aiming to overcome resistance associated with Osimertinib. Both covalent and non-covalent inhibitors targeting Lys745 were explored, using warheads like sulfonyl fluoride, phosphine oxides, esters, and trisubstituted imidazoles.

Tranexamic Acid as a Preventive Strategy Against Periprosthetic Joint Infection in Aseptic Revision Arthroplasty: A Comprehensive Review.

Periprosthetic joint infection (PJI) is a severe complication following joint replacement surgeries, particularly in aseptic revision arthroplasty, where infection rates are higher compared to primary procedures. The extended surgical time, increased blood loss, and the presence of scar tissue contribute to the higher susceptibility to PJI in revision surgeries. Tranexamic acid (TXA), a synthetic antifibrinolytic agent, is widely used in orthopaedic surgery to reduce intraoperative and postoperative bleeding.

Sushruta: The Father of Surgery and Ancient Medical Innovations.

Sushruta, known as the "Father of Surgery," was a pioneering figure in ancient Indian medicine whose contributions have influenced the field of surgery, especially cosmetic surgery and medical practices within the global community. His systematized approach to surgery, with the use of herbal anaesthetics and postoperative care, laid the foundation for surgical practices. Sushruta's emphasis on practical experience, dissection of cadavers, and detailed documentation established standards that continue to underpin surgical education today.

The Life and Legacy of Samuel Hahnemann: Founder of Homoeopathy and His Medical Philosophy.

Dr. Christian Friedrich Samuel Hahnemann (1755) was the visionary founder of homoeopathy, a system of medicine that emerged amidst the orthodox practices of his time. This biography traces Hahnemann's journey from a curious scholar in Meissen to a pivotal figure in global healthcare.