[Correction of oxidative stress in the experimental thermal burn of the skin].

The white breedless rats have been investigated in conditional reflex activity restoration dynamics, exercise tolerance and prominence of oxidative stress after local burn injury of skin and effectiveness of Plaferon use, administered in the first three days after burn injury modeling. One day before administration the background values and the following dynamics of indexes on the first, third and fifth days were recorded. Tolerance exercise has been much higher in the group of animals receiving the Plafreon during the whole period of observation, but the prominence of oxidative stress has been lower than in the group of animals receiving no treatment.

[Influence of the plaferon on healing of burned wounds of III - IV degrees].

The purpose of the given work was studying influence of a preparation Plaferon on the process of healing burned wounds. Experiments was carried out on 30 rats Wistar (the mass of body 220-250 g), that was divided into 3 groups: 1st group (control) -burns without treatment, 2nd group - treatment only with Dermazin, 3rd group - treatment with Dermazin and Plaferon. As a result of the burn wound modeling, it is established that under the effect of the thermal interaction the rats of all experimental groups had severe burns of the skin of III degree.

[Results of treatment of severe burns in the specialized intensive care unit].

The present work is based on the analyses of treatment of 512 patients (228 adults and 224 children) with severe, critical and subcritical thermal injuries in the period from 1998 till 2005. Significant increase of the prevalence of patients with severe and critical burns was revealed in the general structure of the burn traumatisms. There is suggestive decrease in lethality of such patients due to optimization of the intensive treatment methods.

[Peculiarities of wound infections in severe burns].

Infections in patients with burns remain as a one of the main unsolved problems. The present work is based on the analysis of the data obtained from the 642 patients with burns (adults and children) during 2000-2005. The staphylococcus infection is still the leading.

Use of bilidase for the treatment of experimental hypertrophic postburn cicatrices.

The efficiency of bilidase (hyaluronidase preparation) was studied in guinea pigs with experimental postburn cicatrices. Bilidase promoted normalization of the structure and histochemical picture of new cicatricial tissue. The drug can be used for the treatment of hypertrophic postburn cicatrices.