Selective Synthesis of -Michael Acceptors via Hydroalkylation of Conjugated Alkynes.

Hydroalkylation of terminal alkynes is a powerful approach to the synthesis of disubstituted alkenes. However, its application is largely unexplored in the synthesis of α,β-unsaturated carbonyls, which are common among synthetic intermediates and biologically active molecules. The thermodynamically less stable -isomers of activated alkenes have been particularly challenging to access because of their propensity for isomerization and the paucity of reliable -selective hydroalkylation methods.

PEX1 remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome.

The PEX1/PEX6 AAA-ATPase is required for the biogenesis and maintenance of peroxisomes. Mutations in and disrupt peroxisomal matrix protein import and are the leading cause of Peroxisome Biogenesis Disorders (PBDs). The most common disease-causing mutation in PEX1 is the PEX1 allele, which results in a reduction of peroxisomal protein import.

Do people rely more on habits when sleepy? An ecological momentary assessment study.

When self-regulatory resources are depleted, people tend to act more on "autopilot", with minimal forethought. It follows that when sleepy, people should be more likely to act habitually, based on learned cue-behaviour associations that trigger behaviour automatically when the cue is encountered. This ecological momentary assessment study investigated whether, over the course of a week, between-person differences and momentary within-person variation in daytime sleepiness were associated with the reported habit strength of behaviours.

Understanding university students' experiences of sitting while studying at home: A qualitative study.

University students are typically highly sedentary, which is associated with adverse physical and mental health outcomes. Attempts to understand university students' sedentary behaviour have typically focused on on-campus teaching and learning activities. While such research has documented that students perceive studying as one of the main barriers to reducing sedentary behaviour, there is little understanding of how and why studying incurs sitting, especially during home-based studying.

Psychological Responses to Home-Working Practices: A Network Analysis of Relationships with Health Behaviour and Wellbeing.

Working at home, rather than in the workplace, has been suggested to affect office-based workers' health and wellbeing. This exploratory, cross-sectional study sought to identify discrete psychological responses to home-working practices and investigate their relationship with engagement in health-related behaviours and wellbeing. A sample of 491 home-workers completed a survey assessing ten psychological responses to home-working (e.