Publications by authors named "B P Durham"
Article Synopsis
- Marine microbial eukaryotes, or protists, are crucial for ocean ecosystems, but their functions and diversity are not well understood due to limited lab isolation efforts.
- The North Pacific Eukaryotic Gene Catalog compiles data from 261 metatranscriptomes collected across various locations in the North Pacific Ocean, including surface transects and diel-resolved field studies.
- These metatranscriptome sequences were assembled into 175 datasets, annotated, and are now available for research on platforms like Zenodo and GitHub, providing insights into protist diversity and genetic functions.
Article Synopsis
- * This study focused on patients with mixed histiocytic neoplasms (MXH) and identified unique genetic mutations, while evaluating how well these patients responded to different treatments—both traditional and targeted therapies.
- * Results showed that targeted therapies significantly improved treatment outcomes, leading to higher rates of response and lower likelihood of disease progression compared to conventional therapies.
Article Synopsis
- Comprehensive genomic sequencing is crucial for managing hematologic malignancies, with tumor:normal sample analysis enhancing differentiation between somatic and germline mutations.
- This study reveals that using cell-free DNA from nail clippings can effectively serve as a normal control, as traditional sources often contain tumor DNA due to the nature of blood cancers.
- However, low-level contamination from tumor DNA occurs more frequently in patients with myeloid diseases and may provide valuable insights into disease evolution and treatment complications like graft-versus-host disease.
BACKGROUND: Hairy cell leukemia (HCL) is characterized by the underlying genetic lesion of BRAFV600E and responsiveness to BRAF inhibitors. We assessed the safety and activity of the BRAF inhibitor vemurafenib combined with obinutuzumab in patients with previously untreated HCL. METHODS: We conducted a single-arm, multicenter clinical study of vemurafenib plus obinutuzumab.
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