Publications by authors named "B P Clarke"
Article Synopsis
- The audit aimed to assess and improve the completeness and accuracy of the National Joint Registry (NJR) dataset specifically for elbow arthroplasty surgeries.
- In a two-phase approach, Phase 1 compared NJR data with NHS England Hospital Episode Statistics (HES), identifying thousands of unmatched and inaccurate records, particularly for radial head arthroplasties (RHAs).
- Phase 2 involved collaboration among 142 NHS hospitals to correct and update records, resulting in an improved completeness of the NJR dataset from 63% to 93% and accuracy from 94% to 98%.
Article Synopsis
- Microglia, the brain's immune cells, are vital for neuron health but may worsen conditions like ALS and FTD, and their exact role in these diseases is still unclear.
- Researchers created specialized cultures of microglia from human stem cells with VCP mutations to study their behavior and effects on nearby nerve cells and supportive cells, using advanced techniques like RNA sequencing and proteomics.
- The studies revealed that VCP mutant microglia show immune system and lysosomal issues, react differently to inflammation compared to healthy microglia, and can influence motor neurons and astrocytes through secreted factors, even though certain genetic factors didn't fully address their dysfunction.
Objective: Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences.
Methods And Results: In an operant task, protein-restricted male mice responded more for liquid protein rewards, but not carbohydrate, fat, or sweet rewards compared to non-restricted mice.
We report xerogels prepared from TEMPO-oxidized cellulose nanofiber (Ox-CNF) that have enhanced yield stresses and Young's Modulus (E) up to 15.4 MPa. The xerogels were highly porous (>95 %) and were measured by density determination, SEM, Brunauer-Emmet-Teller (BET) experiments, and microCT analysis.
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- Parental exposure to synthetic chemicals before conception can significantly impact fertility and reproductive health, necessitating evaluation of these substances in various biological fluids.
- A new LC-MS/MS method was developed to detect 95 types of xenobiotics in urine, serum, and reproductive fluids, demonstrating high extraction recovery rates and sensitivity.
- Analysis of a cohort of Australian couples undergoing fertility treatment revealed widespread detection of harmful chemicals, such as PFAS and parabens, suggesting potential risks to fertility and indicating the need for further investigation into their effects on reproductive outcomes.