Publications by authors named "B P Ceresa"
Article Synopsis
- The study investigates changes in CT imaging requests in emergency departments during and after the COVID-19 pandemic compared to a pre-pandemic period, focusing on understanding why low-value imaging persists despite reduction efforts.
- Researchers analyzed over 161,000 CT scans and more than 113,000 chest radiographs from a tertiary care hospital, looking specifically at trends from 2014 to 2023, including how the pandemic affected imaging usage.
- Results showed that CT usage, especially dual-region and chest scans, significantly increased during and after the pandemic, while chest radiograph usage decreased; the study also noted a rise in specific clinical inquiries about conditions like pulmonary infiltrates and infections.
The corneal epithelium is the first anatomical barrier between the environment and the cornea; it is critical for proper light refraction onto the retina and prevents pathogens (e.g., bacteria, viruses) from entering the immune-privileged eye.
View Article and Find Full Text PDFIn many cell types, the E3 ubiquitin ligases c-Cbl and Cbl-b induce ligand-dependent ubiquitylation of the hepatocyte growth factor (HGF)-stimulated c-Met receptor and target it for lysosomal degradation. This study determines whether c-Cbl/Cbl-b are negative regulators of c-Met in the corneal epithelium (CE) and if their inhibition can augment c-Met-mediated CE homeostasis. Immortalized human corneal epithelial cells were transfected with Cas9 only (Cas9, control cells) or with Cas9 and c-Cbl/Cbl-b guide RNAs to knockout each gene singularly (-c-Cbl or -Cbl-b cells) or both genes (double KO [DKO] cells) and monitored for their responses to HGF.
View Article and Find Full Text PDFThe cornea is the outmost ocular tissue and plays an important role in protecting the eye from environmental insults. Corneal epithelial wounding provokes pain and fear and contributes to the most ocular trauma emergency assessments worldwide. ZEB1 is an essential transcription factor in development; but its roles in adult tissues are not clear.
View Article and Find Full Text PDFBackground: Trimethylamine N-oxide (TMAO) has been associated with cardiovascular outcomes. However, the diagnostic value of TMAO and its precursors have not been assessed for functionally relevant coronary artery disease (fCAD) and its prognostic potential in this setting needs to be evaluated.
Methods: Among 1726 patients with suspected fCAD serum TMAO, and its precursors betaine, choline and carnitine, were quantified using liquid chromatography tandem mass spectrometry.