Publications by authors named "B P C van Oijen"
Article Synopsis
- * A case study of a 57-year-old woman with diabetes showed that she developed MALA after continuing metformin despite gastrointestinal problems, but her condition improved significantly after receiving continuous venovenous hemodiafiltration.
- * The study suggests that hemodiafiltration is an effective treatment for MALA and that patient outcomes might rely more on underlying health issues rather than just metformin levels, indicating the need for further research in this area.
Aims: Conventional thiopurines (azathioprine and mercaptopurine) remain standard therapy to maintain steroid sparing remission in inflammatory bowel disease (IBD), but are regularly discontinued due to adverse drug reactions (ADRs). Measurement of the metabolites 6-thioguanine nucleotides (6-TGN), 6-methylmercaptopurine ribonucleotides (6-MMPR) and the 6-MMPR/6-TGN ratio, may predict the development of these ADRs. Our aim was to evaluate whether early thiopurine metabolite measurements were associated with clinical outcomes.
View Article and Find Full Text PDFObjectives: To develop (part I) and validate (part II) an electronic fall risk clinical rule (CR) to identify nursing home residents (NH-residents) at risk for a fall incident.
Design: Observational, retrospective case-control study.
Setting: Nursing homes.
Purpose: The chronic use of benzodiazepines and benzodiazepine-related drugs (BZ/Z) in older people is common and not without risks. The objective of this study was to evaluate whether the implementation of a clinical rule promotes the discontinuation of chronically used BZ/Z for insomnia.
Methods: A clinical rule, generating an alert in case of chronic BZ/Z use, was created and applied to the nursing home (NH) setting.
Objectives: Delirium is an underdiagnosed, severe and costly disorder, and 30%-40% of cases can be prevented. A fully automated model to predict delirium (DEMO) in older people has been developed, and the objective of this study is to validate the model in a hospital setting.
Setting: Secondary care, one hospital with two locations.