Thromboembolic events, major bleeding and mortality in essential thrombocythaemia and polycythaemia vera-A matched nationwide population-based study.

Thromboembolic events and bleeding are known complications in essential thrombocythaemia (ET) and polycythaemia vera (PV). Using multiple Swedish health care registers, we assessed the rate of arterial and venous events, major bleeding, all-cause stroke and all-cause mortality in ET and PV compared to matched controls. For each patient with ET (n = 3141) and PV (n = 2604), five matched controls were randomly selected.

The clinical relevance of broad mutational screening of myeloproliferative neoplasms at diagnosis.

Introduction: Myeloproliferative neoplasm (MPN) is a heterogenous group of hematological malignancies including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). V617F is the most frequent driver mutation in all three entities, but in PMF and ET mutations in and are also frequent. Mutations seen in additional genes are also often the same regardless of subtype of MPN.

On Structural and Molecular Order in Cellulose Acetate Butyrate Films.

Cellulose acetate butyrate (CAB) is a possible candidate, being a raw material derived from renewable resources, to replace fossil-based materials. This is due to its thermoplastic properties and the relative ease with which it could be implemented within the existing industry. With a significant amount of variation in CAB on the market today, a knowledge gap has been identified regarding the understanding of the polymer structural arrangement in films.

Erythrocytosis, thrombocytosis, and rate of recurrent thromboembolic event-A population based cohort study.

Introduction: The management to reduce risk of thromboembolic complications in polycythemia vera and essential thrombocythemia are well established, but for other conditions with elevated hemoglobin, hematocrit, or platelets there are no consensus regarding treatment and follow up.

Aims: To assess frequency of elevated blood values in patients with thromboembolic event, how many of these should be investigated further regarding myeloproliferative neoplasm and if the risk of recurrent event is depending on underlying condition.

Methods: Retrospective cohort study of 3931 adult patients in the county of Norrbotten, Sweden, with thromboembolism during 2017 and 2018.