Selective nephroangiography in the dog causing renal platelet aggregation and irregular nephrographic phase.

Selective renal artery injections of large single doses of the ionic contrast medium metrizoate produced an irregular nephrographic phase, 'patchy contrast medium retention', in 14 of 16 dogs. The irregular nephrographic phase was associated with a transient accumulation of platelets and fibrinogen in the kidney and with microscopically demonstrable transient thrombi in afferent arterioles and glomerular capillary tufts. These effects were followed by tubular damage, which was demonstrated in 4 of 6 dogs examined 48 hours after injection.

A renal biopsy study with light and immunofluorescent microscopy in rheumatoid arthritis.

REnal biopsies were performed on 14 patients with active rheumatoid arthritis an proteinuria of whom 7 patients had reduced creatinine clearance. Glomerular hypercellularity was found in six and amyloid in seven biopsies. Immunofluorescence microscopy revealed glomerula deposits of immunoglobulins and complement in 10 of 12 biopsies, indicating an active immunologic process causing the impaired renal function.

Glomerulonephritis in dermatitis herpetiformis. A case study.

A patient with dermatitis herpetiformis, proteinuria and reduced renal function is described. A renal biopsy studied by light and immunofluorescence microscopy revealed a glomerulonephritis with deposits of predominantly IgA and complement C3. Deposits of IgA and C3 were also demonstrated in a biopsy from normal skin, and a common pathway for the skin and renal lesions is suggested.