Publications by authors named "B Ostyn"
Article Synopsis
- Nepal's visceral leishmaniasis elimination initiative, launched in 2005, aimed to determine if the transmission of Leishmania donovani had decreased over the years, specifically comparing seroprevalence data from 2006 to 2016.
- A repeat survey involving 6,609 individuals showed a significant reduction in seroprevalence across all age groups, particularly in children under 10, with a drop from 4.1% in 2006 to 0.5% in 2016, indicating a successful decrease in transmission.
- The study concludes that the decline in transmission correlates with the elimination program's efforts, and the direct agglutination test (DAT) is a
Background: Asymptomatic Leishmania donovani infections outnumber clinical presentations, however the predictors for development of active disease are not well known. We aimed to identify serological, immunological and genetic markers for progression from L. donovani infection to clinical Visceral Leishmaniasis (VL).
View Article and Find Full Text PDFObjective: To assess the rate of default from treatment in the visceral leishmaniasis (VL) elimination programme and to identify risk factors and its underlying causes.
Methods: Case-control study conducted between December 2009 and June 2012 in three primary health centres (PHCs) of Muzaffarpur district, India. Patients who defaulted from treatment from the PHCs were considered as 'cases' and those who completed their treatment as 'controls'.
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic.
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